Post covid myocarditis

The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study https://pubmed.ncbi.nlm.nih.gov/35456309/ The authors declare no conflict of interest. Myocarditis and pericarditis are potential post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. We aimed to study the incidence of post-acute COVID-19 myocarditis and pericarditis. Retrospective cohort study N = 196,992 adults after COVID-19 infection Clalit Health Services members in Israel March 2020 and January 2021 The control cohort (no infection) N = 590,976 adults Age- and sex-matched COVID infection cohort Nine post-COVID-19 patients developed myocarditis (0.0046%) Eleven patients were diagnosed with pericarditis (0.0056%). Non- COVID infection cohort 27 patients had myocarditis (0.0046%) 52 had pericarditis (0.0088%) Age adjusted hazard ratio 0.96 95% confidence interval, 0.93 to 1.00 Male sex, aHR 4.42; were associated with myocarditis Male sex aHR 1.93; were associated with pericarditis Post COVID-19 infection was not associated with either myocarditis or pericarditis aHR 1.08; for myocarditis aHR 0.53; for myocarditis We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection. Myocarditis and pericarditis (21st March 2022) https://www.gov.uk/government/publications/covid-19-vaccination-myocarditis-and-pericarditis-information-for-healthcare-professionals/information-for-healthcare-professionals-on-myocarditis-and-pericarditis-following-covid-19-vaccination In 2017 https://www.ahajournals.org/doi/10.1161/circ.140.suppl_1.11463 About 2,000 hospital admissions for myocarditis Two-thirds of cases were in men Median age for men, 33 Mostly viral https://www.mdpi.com/2077-0383/10/4/603 Presentation of acute myocarditis Subclinical disease too, heart failure, chest pain, shortness of breath, palpitations and fatigue. Dilated cardiomyopathy and chronic heart failure Sudden death syndrome https://www.sciencedirect.com/science/article/abs/pii/S0033062009000966?via%3Dihub Myocarditis implicated in 12% of sudden deaths under the age of 40 Acute pericarditis Often similar presentation Some concurrent myocardial involvement (myopericarditis) Constrictive pericarditis is uncommon https://heart.bmj.com/content/101/14/1159 Can myocarditis or pericarditis be caused by coronavirus (COVID-19) infection? It is now recognised that COVID-19 infection can lead to myocarditis or pericarditis https://pubmed.ncbi.nlm.nih.gov/34516657/ Professional athletes are an atypical group Published online 2021 May 27 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160916/ 1,597 athletes with recent SARS-CoV-2 infection (March 1, 2020, through December 15, 2020) 0.31% were diagnosed with myocarditis using a symptom-based screening 2.3% were diagnosed with clinical or subclinical myocarditis using cardiac magnetic resonance screening Is there an association of myocarditis or pericarditis following COVID-19 vaccination? Many studies have now shown that there is an increased risk of myocarditis following vaccination with an mRNA vaccine, https://www.nejm.org/doi/full/10.1056/NEJMoa2110737 https://www.cdc.gov/mmwr/volumes/70/wr/mm7027e2.htm https://www.nejm.org/doi/full/10.1056/NEJMoa2109730 https://www.gov.uk/government/publications/myocarditis-and-pericarditis-after-covid-19-vaccination especially in young men under the age of 40. Many of the studies have only limited follow up ……