TRPA1 Gain of Function Linked to Human Pain

Mutations in ion channels underlie multiple neurological disorders, including pathological pain states. Although previous work with knock-out mice has suggested that TRP channels play an important role in pain pathways, no human heritable disorders of pain sensation have been linked to mutations in TRP channels. Watch and listen as John Wood and colleagues take you on a personally guided tour of their findings that a point mutation in TRPA1 causes the human pain syndrome FEPS. Read more in Kremeyer et al., Neuron 66(5).