Monkeypox, firm data

Monkeypox virus, seldom reported outside African until now, https://www.nejm.org/doi/full/10.1056/NEJMoa2207323?emp=marcom&utm_source=nejmlist&utm_medium=email&utm_campaign=aomev2&utm_content=version-a&ssotoken=U2FsdGVkX19dsxXEVZT5ggLZ3zieDxejeViMkwTigM4Q7ECfBTJmfTXUrKWkbZ3up0jDhhQjYR6OydzgkC%2F1LL8S5l7OuFDLsP2LiBwfKJ3ymNN4hp0Z%2FNASEYMuetIqeQIQ9ETL8BABCQut7e8xEQeWPlduFdyPMYgAugUePHtSEs5rFR%2BGWfFOCIPZs9Wb7aJf%2FyzhvvLSrzqDKmNt4Q%3D%3D&cid=DM1289135_Notable_Articles_Engaged&bid=1085207852 Endemic in Africa Cases now worldwide METHODS Formed an international collaborative group, international case series, presentation, clinical course, outcomes of PCR confirmed infections RESULTS We report 528 infections diagnosed between April 27 to June 24, 2022 Cases, 528, at 43 sites in 16 countries 98% in gay or bisexual men, 7 5% were White, 41% had HIV median age 38 Transmission suspected to have occurred through sexual activity 95% of cases Presentation in this series 95% rash (with 64% having less than 10 lesions) 73% anogenital lesions 41% had mucosal lesions (with 54 having a single genital lesion) Common systemic features preceding the rash fever (62%) lethargy (41%) myalgia (31%) headache (27%) lymphadenopathy (56%) Concomitant sexually transmitted infections 109 of 377 (29%) Among the 23 people with a clear exposure history median incubation period, 7 days (range, 3 to 20) Monkeypox virus DNA Detected in 29 of the 32 (in whom seminal fluid was analyzed) Management Antiviral treatment given to 5% of cases 70 (13%) were hospitalized Mostly for pain management severe anorectal pain (21) soft-tissue superinfection (18) pharyngitis limiting oral intake (5) eye lesions (2) acute kidney injury (2) myocarditis (2) infection-control purposes (13) No deaths were reported CONCLUSIONS Monkeypox manifested with a variety of dermatologic and systemic clinical findings. Need for rapid identification and diagnosis of cases to contain further community spread.