11. Physical Approaches to help bringing Nanomedicines to the Clinic

11. Physical Approaches to help bringing Nanomedicines to the Clinic Chair: Dr. Marieluise Wippermann, CEO, TecoMedical Ltd, Sissach (CH) About: Nanophysics forms the basis of many phenomena and solutions in medicine and life sciences and represents an important interface to these various fields. For industrial pharmaceutical companies, novel developments allow the Integration of experimental and computational pharmacology to predict the effects of drug candidates. This session showcases novel developments in physics, nanomedicine, and chemistry. • Realistic In Vitro Models as Way to Real Individualized Medicine Dr. Silke Krol, Laboratory for personalized medicine, IRCCS Ospedale Specializzato in Gastroenterologia "Saverio de Bellis“, Castellano Grotte, BA (IT) • Appreciating and Exploiting the Mechanical Design of Proteins Prof. Dr. Dr. h.c. Viola Vogel, Head of the Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology (D-HEST), ETH, Zürich (CH) • Biomedical Nanoparticle Biotransformation: Analysis of the Early Dynamic Events in Situ Dr. Peter Wick, Head of the Laboratory for Particles-Biology Interactions, Empa, St. Gallen (CH) • Nanomedicine Ex Machina: Design Strategies based on Clinical Relevance Prof. Dr. Matthias Wacker, Associate Professor, Department of Pharmacy, Faculty of Science, National University of Singapore (SGP) • Identification of Corona Proteins Mediating Nanoparticle Uptake and Characterization of the Mechanism of Endocytosis Prof. Dr. Anna Salvati, Associate Professor, Faculty of Science and Engineering, Department of Nanomedicine & Drug Targeting, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen (NL) •Optimizations of Stable Nucleic Acid Lipid Nanoparticles Formulations for in vitro and in vivo Delivery of Plasmid DNA and siRNA to Cancer Using Design of Experiments Yue Qin MSc, PhD student, King’s College London, London (UK)