Chronic Inflammation - T Regulatory Cells (Lecture 4)

Chronic Inflammation - T Regulatory Cells (Lecture 4) An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology. If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special/ Want to support this work?: Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true PayPal: https://paypal.me/mobeensyed?locale.x=en_US My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #chronicinflammation Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. A good reference diagram in the book: FIGURE 15.6   Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28. References: Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition. URL list from Wednesday, May. 31 2022 DrBeen: Medical Education Online https://www.drbeen.com/ Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy https://www.nature.com/articles/s41392-017-0002-5#:~:text=While%20IL%2D2%20is%20generally,unwanted%20immune%20responses%20and%20eventually IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed https://pubmed.ncbi.nlm.nih.gov/16304057/ IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473973/ IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed https://pubmed.ncbi.nlm.nih.gov/34305950/ Chronic Inflammation - StatPearls - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK493173/ Inflammation - Wikipedia https://en.wikipedia.org/wiki/Inflammation Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/ Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology https://www.frontiersin.org/articles/10.3389/fimmu.2018.01523/full