Japan pathology

Free download posters and my text books, https://drjohncampbell.co.uk/ A case of fatal multi-organ inflammation following COVID-19 vaccination https://www.sciencedirect.com/science/article/pii/S1344622323000548 14-year-old Japanese girl Healthy and active, athletic team Died unexpectedly Two days after receiving the third dose of the BNT1262b2 mRNA COVID-19 vaccine, (10th August 2022) Autopsy findings Congestive edema of the lungs T-cell lymphocytic and macrophage infiltration Lungs Pericardium Myocardium (left atria and left ventricle) Atrial myopericarditis Liver Kidneys Stomach Duodenum Bladder Diaphragm No preceding Infection Allergy Drug toxicity exposure Diagnosis Post-vaccination Pneumonia Myopericarditis Hepatitis Nephritis Gastroenteritis Cystitis Myositis Proximal cause of death Atrial myopericarditis probably caused fatal arrhythmia, Leading to cardiac failure and death. More details Post-vaccination myocarditis and pericarditis have been increasingly reported Male adolescents Higher incidence of pericarditis with a good prognosis Middle-aged and older patients More likely to have severe myocarditis The day after vaccination Developed a fever of 37.9 °C Some breathing difficulties The following morning Not breathing, pale appearance In cardiopulmonary arrest when paramedics arrived Resuscitated Died 45 hours after the third vaccination. After the first dose of vaccine on 12th September 2021 Arm pain without fever Day after the second dose on 3rd October 2021 Fever less than 38 °C Autopsy findings No superficial injuries were observed Heart showed no degeneration or scarring Both lungs showed severe pulmonary edema and congestion. A COVID-19 antigen quantification test, negative Numerous internal organ COVID-19 antigen tests, negative Serum, negative for adenovirus, cytomegalovirus, influenza A and B, RSV, EBV, enterovirus, parvovirus, HIV Histological findings Lymphocyte cellular infiltrates observed in the lungs, pericardium of both atria and adjacent myocardium, liver, kidneys, stomach, duodenum, and diaphragm Brain showed congestion Hippocampus a slight lymphocytic infiltrate Biochemical analysis Elevated SARS-CoV-2 antibody (43600 U/mL, normal less than 0.80) Elevated IL-6 (226 pg/mL, normal ≦4.0) Diagnosis Vaccine-related multiple-organ inflammation Vaccine-related myopericarditis, which led to severe arrythmias and progressive heart failure. Discussion However, adverse events caused by vaccines have been a problem.